Cell Line Development

Bionova Scientific™ uses established mammalian expression systems to rapidly develop cell lines to generate Research Cell Banks (RCB). We also generate cell lines to support late stage process development to generate Master Cell Banks (MCB) suitable for cGMP manufacturing use.

GS System

CHOZN® Platform (Sigma)*

* additional license fee from the vendor may be applied at milestone

Designed and optimized for high productivity and robust manufacturing processes

Cell Line System: CHOZN Platform® or client supplied

DNA sequence to RCB: 4 months with high throughput CLD process

Note: 2 to 3 months will be added with cell line stability study

CloneSelect® Imager for pictorial evidence of monoclonality

Non-invasively image cells in 96 well plates to demonstrate monoclonality

Capture digital record of clone history, including single cell and first cell division to present to regulatory authorities


Bionova Scientific’s cell line engineering team employs the TARGATT™ system to deliver site-specific gene integration for the development of production cell lines. The TARGATT™ system promises to provide unique benefits over existing expression systems.

Our deep experience in cell line development allows us to generate high-performing cell lines with desirable product qualities for the expression of monoclonal antibodies, antibody fragments, bispecific antibodies, Fc fusion proteins, recombinant proteins, antibody-drug conjugates.