Bionova Scientific™ uses established mammalian expression systems to rapidly develop cell lines to
generate Research Cell Banks (RCB). We also generate cell lines to support late stage process
development to generate Master Cell Banks (MCB) suitable for cGMP manufacturing use.
CHOZN® Platform (Sigma)*
* additional license fee from the vendor may be applied at milestone
Designed and optimized for high productivity and robust manufacturing processes
Cell Line System: CHOZN Platform® or client supplied
DNA sequence to RCB: 4 months with high throughput CLD process
Note: 2 to 3 months will be added with cell line stability study
CloneSelect® Imager for pictorial evidence of monoclonality
Non-invasively image cells in 96 well plates to demonstrate monoclonality
Capture digital record of clone history, including single cell and first cell division to present to regulatory authorities
Bionova Scientific’s cell line engineering team employs the TARGATT™ system to deliver site-specific
gene integration for the development of production cell lines. The
TARGATT™ system promises to provide unique benefits over existing expression systems.
Our deep experience in cell line development allows us to generate high-performing cell lines with
desirable product qualities for the expression of monoclonal antibodies, antibody fragments,
bispecific antibodies, Fc fusion proteins, recombinant proteins, antibody-drug conjugates.